{"id":1281,"date":"2025-07-25T20:14:10","date_gmt":"2025-07-25T20:14:10","guid":{"rendered":"https:\/\/studenthub.elsevier.com\/en\/?p=1281"},"modified":"2025-08-07T18:04:04","modified_gmt":"2025-08-07T18:04:04","slug":"duchennes-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/","title":{"rendered":"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality?"},"content":{"rendered":"\n        <div class=\"simple-quiz\" id=\"sqt_1_3084_container\">\n            \n            <div class=\"quiz-options\">\n                                    <div class=\"quiz-option\">\n                        <input type=\"radio\" \n                               id=\"sqt_1_3084_option_1\" \n                               name=\"sqt_1_3084_options\" \n                               value=\"1\">\n                        <label for=\"sqt_1_3084_option_1\">\n                            A. X-linked inheritance                        <\/label>\n                    <\/div>\n                                    <div class=\"quiz-option\">\n                        <input type=\"radio\" \n                               id=\"sqt_1_3084_option_2\" \n                               name=\"sqt_1_3084_options\" \n                               value=\"2\">\n                        <label for=\"sqt_1_3084_option_2\">\n                            B. Trisomy 18                        <\/label>\n                    <\/div>\n                                    <div class=\"quiz-option\">\n                        <input type=\"radio\" \n                               id=\"sqt_1_3084_option_3\" \n                               name=\"sqt_1_3084_options\" \n                               value=\"3\">\n                        <label for=\"sqt_1_3084_option_3\">\n                            C. Trisomy 13                        <\/label>\n                    <\/div>\n                                    <div class=\"quiz-option\">\n                        <input type=\"radio\" \n                               id=\"sqt_1_3084_option_4\" \n                               name=\"sqt_1_3084_options\" \n                               value=\"4\">\n                        <label for=\"sqt_1_3084_option_4\">\n                            D. Trisomy 21                        <\/label>\n                    <\/div>\n                                    <div class=\"quiz-option\">\n                        <input type=\"radio\" \n                               id=\"sqt_1_3084_option_5\" \n                               name=\"sqt_1_3084_options\" \n                               value=\"5\">\n                        <label for=\"sqt_1_3084_option_5\">\n                            E. 47, XXY                        <\/label>\n                    <\/div>\n                            <\/div>\n            \n            <div class=\"quiz-toggle\">\n                <span class=\"quiz-cta\" \n                      role=\"button\" \n                      tabindex=\"0\" \n                      onclick=\"simpleQuizToggleResults('sqt_1_3084')\"\n                      onkeydown=\"if(event.key === 'Enter' || event.key === ' ') { simpleQuizToggleResults('sqt_1_3084'); event.preventDefault(); }\">\n                    Reveal the answer                <\/span>\n                \n                <div id=\"sqt_1_3084_results\" class=\"quiz-results\" aria-live=\"polite\">\n                    A. X-linked inheritance                <\/div>\n            <\/div>\n            \n        <\/div>\n        \n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":165,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"wp-custom-template-question-bank-individual-entry","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[16,11],"tags":[],"class_list":["post-1281","post","type-post","status-publish","format-standard","hentry","category-genetics","category-question-bank"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN<\/title>\n<meta name=\"description\" content=\"Boost your genetics knowledge with our sample question on Duchenne&#039;s muscular dystrophy. Test yourself with our practice question bank!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN\" \/>\n<meta property=\"og:description\" content=\"Boost your genetics knowledge with our sample question on Duchenne&#039;s muscular dystrophy. Test yourself with our practice question bank!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/\" \/>\n<meta property=\"og:site_name\" content=\"Student Hub EN\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-25T20:14:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-07T18:04:04+00:00\" \/>\n<meta name=\"author\" content=\"camille\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"camille\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/\",\"url\":\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/\",\"name\":\"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN\",\"isPartOf\":{\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/#website\"},\"datePublished\":\"2025-07-25T20:14:10+00:00\",\"dateModified\":\"2025-08-07T18:04:04+00:00\",\"author\":{\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/09402976d88460df8e9f6b623b21972c\"},\"description\":\"Boost your genetics knowledge with our sample question on Duchenne's muscular dystrophy. Test yourself with our practice question bank!\",\"breadcrumb\":{\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/studenthub.elsevier.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/#website\",\"url\":\"https:\/\/studenthub.elsevier.com\/en\/\",\"name\":\"Student Hub EN\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/studenthub.elsevier.com\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/09402976d88460df8e9f6b623b21972c\",\"name\":\"camille\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/18552be5944e8e9adacf214b2c6895f0b8584827f654fc27425d50ad4a8fa975?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/18552be5944e8e9adacf214b2c6895f0b8584827f654fc27425d50ad4a8fa975?s=96&d=mm&r=g\",\"caption\":\"camille\"},\"url\":\"https:\/\/studenthub.elsevier.com\/en\/author\/camille\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN","description":"Boost your genetics knowledge with our sample question on Duchenne's muscular dystrophy. Test yourself with our practice question bank!","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/","og_locale":"en_US","og_type":"article","og_title":"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN","og_description":"Boost your genetics knowledge with our sample question on Duchenne's muscular dystrophy. Test yourself with our practice question bank!","og_url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/","og_site_name":"Student Hub EN","article_published_time":"2025-07-25T20:14:10+00:00","article_modified_time":"2025-08-07T18:04:04+00:00","author":"camille","twitter_card":"summary_large_image","twitter_misc":{"Written by":"camille","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/","url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/","name":"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality? - Student Hub EN","isPartOf":{"@id":"https:\/\/studenthub.elsevier.com\/en\/#website"},"datePublished":"2025-07-25T20:14:10+00:00","dateModified":"2025-08-07T18:04:04+00:00","author":{"@id":"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/09402976d88460df8e9f6b623b21972c"},"description":"Boost your genetics knowledge with our sample question on Duchenne's muscular dystrophy. Test yourself with our practice question bank!","breadcrumb":{"@id":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/duchennes-muscular-dystrophy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/studenthub.elsevier.com\/en\/"},{"@type":"ListItem","position":2,"name":"A 6-year-old boy is brought to see you in clinic by his mother. She has noticed that he has developed difficulty running and getting up from sitting on the floor. He has a 12-year-old brother who presented at a similar age and is now wheelchair bound. On examination he has proximal muscle weakness with enlarged calf muscles.\u00a0He is diagnosed with Duchenne\u2019s muscular dystrophy. Which is the most likely mechanism of inheritance of the genetic abnormality?"}]},{"@type":"WebSite","@id":"https:\/\/studenthub.elsevier.com\/en\/#website","url":"https:\/\/studenthub.elsevier.com\/en\/","name":"Student Hub EN","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/studenthub.elsevier.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/09402976d88460df8e9f6b623b21972c","name":"camille","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/studenthub.elsevier.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/18552be5944e8e9adacf214b2c6895f0b8584827f654fc27425d50ad4a8fa975?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/18552be5944e8e9adacf214b2c6895f0b8584827f654fc27425d50ad4a8fa975?s=96&d=mm&r=g","caption":"camille"},"url":"https:\/\/studenthub.elsevier.com\/en\/author\/camille\/"}]}},"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1292,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/karyotype\/","url_meta":{"origin":1281,"position":0},"title":"The karyotype is the number of chromosomes in the nucleus of a eukaryotic cell. Which of the following human karyotypes is an example of trisomy?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Genetics&quot;","block_context":{"text":"Genetics","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1290,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetic-disease-inheritance\/","url_meta":{"origin":1281,"position":1},"title":"Jane suffers from a genetic disease. Two of her three sons and one out of her three daughters also have the disease. Three of her seven grandsons and two of her three granddaughters have the disease. Which of the following modes of inheritance is the most likely mode of inheritance for the disease in this family?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Genetics&quot;","block_context":{"text":"Genetics","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1296,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/sex-linked-dominant-disorders\/","url_meta":{"origin":1281,"position":2},"title":"Sex linked inheritance of genetic defects can be described as X-linked recessive or X-linked dominant. Which of the following statements concerning sex linked dominant disorders is true?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Genetics&quot;","block_context":{"text":"Genetics","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/genetics\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1247,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/elevated-blood-calcium\/","url_meta":{"origin":1281,"position":3},"title":"A 56-year-old female patient presents with constipation, excessive thirst, frequent urination and feelings of depression.\u00a0Blood tests reveal elevated blood calcium levels. Which of the following would cause elevated blood calcium levels?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Biochemistry&quot;","block_context":{"text":"Biochemistry","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/biochemistry\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1327,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/blood-glucose-levels\/","url_meta":{"origin":1281,"position":4},"title":"A 7-year-old child has injections of insulin each day in order to help control her raised blood glucose levels. Which of the following autoimmune conditions is most likely affecting this patient?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Immunology&quot;","block_context":{"text":"Immunology","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/immunology\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1250,"url":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/biochemistry\/alcoholic-liver-disease\/","url_meta":{"origin":1281,"position":5},"title":"A 63-year-old man is admitted to the hepatology ward after presenting with profound jaundice. He has been drinking heavily for the last 40 years, sometimes consuming 45 units a week. Which of the following blood results would you expect to be lowered in alcoholic liver disease?","author":"camille","date":"July 25, 2025","format":false,"excerpt":"","rel":"","context":"In &quot;Biochemistry&quot;","block_context":{"text":"Biochemistry","link":"https:\/\/studenthub.elsevier.com\/en\/question-bank\/biochemistry\/"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/posts\/1281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/users\/165"}],"replies":[{"embeddable":true,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/comments?post=1281"}],"version-history":[{"count":2,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/posts\/1281\/revisions"}],"predecessor-version":[{"id":1283,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/posts\/1281\/revisions\/1283"}],"wp:attachment":[{"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/media?parent=1281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/categories?post=1281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studenthub.elsevier.com\/en\/wp-json\/wp\/v2\/tags?post=1281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}